奈西利肽 - CAS:124584-08-3 - Welcome Adachibio！

Chemical Properties

Synonyms:	Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His{MonoDisulfidebridge} \| H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH {MonoDisulfidebridge}
Cas No.:	124584-08-3	Purity Limit:
Molecular Weight:	3464.04	Formula:	C₁₄₃H₂₄₄N₅₀O₄₂S₄
Storage:	-20℃	Solubility:

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Description

用于急性失代偿性心力衰竭。奈西利肽通过与利钠肽A型和B型受体结合，增加靶细胞环鸟苷酸的水平，从而促进平滑肌细胞舒张，使静脉和动脉血管扩张，发挥其利尿钠、利尿、血管扩张、平滑肌松弛的作用。此外，本药尚能抑制肾素-醛固酮系统，与心房利尿钠肽有类似的作用。

References